9X1H

Cryo-EM Structure of human complement C1s CUB domain in complex with RAY121

Summary for 9X1H

• Entry DOI: 10.2210/pdb9x1h/pdb
• EMDB information: 61792 66460
• Descriptor: RAY121 Fab Light chain, RAY121 Fab Heavy chain, Complement C1s subcomponent heavy chain, ... (4 entities in total)
• Functional Keywords: ph-dependent, recycling antibody, immune system, complement c1s, fab, complex, cub domain, egf-like domain
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 161433.00

Authors

Kawauchi, H.,Adrian, H.,Gupta, G.,Koga, H.,Fujii, T.,Fukumura, T.,Ishino, S.,Irie, M.,Torizawa, T. (deposition date: 2025-10-02, release date: 2025-11-19)

Primary citation

Ho, A.W.S.,Fukuzawa, T.,Koga, H.,Ohmine, K.,Kawauchi, H.,Muraoka, M.,Ikuta, Y.,Gupta, G.,Okuda, M.,Onami, I.,Ayabe, M.,Takeiri, A.,Konishi, H.,Sugawara, Y.,Usami, S.,Ito, E.,Shibahara, N.,Ozeki, K.,Wada, Y.,Hirako, A.,Takahashi, N.,Sampei, Z.,Haraya, K.,Murao, N.,Fujii, T.,Torizawa, T.,Shimada, H.,Igawa, T.
Long lasting complement neutralisation by RAY121, an engineered anti-C1s antibody with C1q displacement function.
Ebiomedicine, 122:106009-106009, 2025

PubMed Abstract: Antibody drugs blocking the complement classical pathway (CP) often require frequent intravenous administration to overcome the high abundance or rapid turnover of complement proteins. This makes treatment compliance burdensome for patients.

PubMed: 41205294
DOI: 10.1016/j.ebiom.2025.106009

Experimental method

ELECTRON MICROSCOPY (2.6 Å)