9WTW

Amyloid-beta 40 Flemish (A21G) mutant Filaments from Human Brain

Summary for 9WTW

• Entry DOI: 10.2210/pdb9wtw/pdb
• EMDB information: 66225
• Descriptor: Amyloid-beta protein 40 (2 entities in total)
• Functional Keywords: amyloid-beta, alzheimer's disease, neurodegeneration, protein aggregation, protein fibril
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 10
• Total formula weight: 43218.26

Authors

Guillen-Poza, P.A.,Yang, Y.,Hervas, R. (deposition date: 2025-09-17, release date: 2026-08-05)

• Primary citation: Khaki, P.S.S.,Guillen-Poza, P.A.,Wong, C.,Robinson, A.C.,Ng, R.C.-L.,Yang, Y.,Hervas, R.; Distinct amyloid-beta filament fold in individuals with APP Flemish mutation; Nat.Struct.Mol.Biol., 2026; DOI: 10.1038/s41594-026-01855-y

Experimental method

ELECTRON MICROSCOPY (1.98 Å)