9WPQ

5-HT2AR bound to LSD in complex with mini-Gq and scFv16 obtained by cryo-electron microscopy (cryoEM)

Summary for 9WPQ

• Entry DOI: 10.2210/pdb9wpq/pdb
• EMDB information: 66146
• Descriptor: 5-hydroxytryptamine receptor 2A, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, G protein subunit q (Gi2-mini-Gq chimera), ... (6 entities in total)
• Functional Keywords: gpcr, serotonin receptor, membrane protein, 5-ht2ar, signaling protein/immune system, signaling protein-immune system complex
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 142494.84

Authors

Li, H.,Tang, L.,Zhang, J.,Meng, B.,Cao, D.,Chen, Y.,Yu, J.,Liu, Z.,Wang, S.,Cheng, J. (deposition date: 2025-09-09, release date: 2026-09-16)

• Primary citation: Li, H.,Tang, J.,Zhang, J.,Meng, B.,Cao, D.,Yu, J.,Liu, Z.,Wang, S.,Cheng, J.; Structure-based design of subtype-selective psychedelic analogues; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.15 Å)