9WM7

Crystal structure of HKU5-CoV-1 main protease(Mpro) in complex with Nirmatrelvir

Summary for 9WM7

• Entry DOI: 10.2210/pdb9wm7/pdb
• Descriptor: 3C-like proteinase nsp5, (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide (3 entities in total)
• Functional Keywords: main protease, 3c-like protease, coronavirus, hku5-cov-1, bat coronavirus, viral protease, nirmatelvir, drug target, active site, viral protein
• Biological source: Pipistrellus bat coronavirus HKU5
• Total number of polymer chains: 1
• Total formula weight: 33984.85

Authors

Kim, H.,Lee, J.,Jung, S.,Kim, J.,Jo, I. (deposition date: 2025-09-03, release date: 2026-09-09)

• Primary citation: Kim, H.,Lee, J.,Jung, S.,Kim, J.,Jo, I.; Crystal structure of HKU5-CoV-1 main protease(Mpro) in complex with Nirmatrelvir; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.91 Å)