9WGQ

Crystal structure of OcKAI2d6 from Orobanche cumana

Summary for 9WGQ

Entry DOI	10.2210/pdb9wgq/pdb
Related	9WGO
Descriptor	Alpha/beta-hydrolases superfamily protein (2 entities in total)
Functional Keywords	ockai2d6, dehydrocostus lactone, enzyme, orobanche cumana, seed germination, hydrolase
Biological source	Orobanche cernua var. cumana
Total number of polymer chains	2
Total formula weight	60328.79
Authors	Hameed, U.F.S.,Arold, S.T. (deposition date: 2025-08-25, release date: 2026-05-20, Last modification date: 2026-07-01)
Primary citation	Shahul Hameed, U.F.,Jamil, M.,Zarban, R.A.,Saito, Y.,Alashoor, K.F.,Balakrishna, A.,Asami, T.,Arold, S.T.,Al-Babili, S. Orobanche cumana KAI2d2 mediates the perception of dehydrocostus lactone and strigolactones and is inhibited by triazole ureas. Plant Commun., :101889-101889, 2026 Cited by PubMed Abstract: Seed germination of the parasitic plant Orobanche cumana is induced by host-derived strigolactones and dehydrocostus lactone. We show that the KAI2d2 receptor perceives both ligands through distinct modes of interaction. Triazole urea compounds covalently inhibit KAI2d receptors, suppressing germination without affecting sunflower growth. PubMed: 42104616 DOI: 10.1016/j.xplc.2026.101889 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation