9WF7

Guaiadiene synthase complexed with farnesyl S-thiolodiphosphate

Summary for 9WF7

• Entry DOI: 10.2210/pdb9wf7/pdb
• Descriptor: Inactive (1R,4R,5S)-(-)-guaia-6,10(14)-diene synthase, S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: guaiadiene biosynthesis, sesquiterpene cyclase, stc5, terpene synthase, lyase
• Biological source: Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (Bakanae and foot rot disease fungus, Fusarium fujikuroi)
• Total number of polymer chains: 2
• Total formula weight: 95240.21

Authors

Kunthic, T.,Xiang, Z. (deposition date: 2025-08-21, release date: 2026-08-26)

• Primary citation: Xiao, W.,Kunthic, T.,Xiang, Z.; Structure-guided engineering of guaiadiene synthase and cytochrome P450BM3 for target- and diversity-oriented synthesis of guaiane sesquiterpenoids; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.501 Å)