9WEZ

Cryo-EM structure of human pyruvate kinase R (PKR) in complex with FBP

Summary for 9WEZ

• Entry DOI: 10.2210/pdb9wez/pdb
• EMDB information: 65437 65736 65919
• Descriptor: Pyruvate kinase PKLR, 1,6-di-O-phosphono-alpha-D-fructofuranose (2 entities in total)
• Functional Keywords: pyruvate kinase pklr, rpk, glycolysis, allosteric regulation, erythroid-specific, pkd, fbp, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 248976.56

Authors

Ma, H.Y.,Su, Z.M. (deposition date: 2025-08-20, release date: 2026-08-26)

• Primary citation: Ma, H.Y.,Su, Z.M.; Structural insights into allosteric activation of pyruvate kinase R by mitapivat and novel agonists; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.64 Å)