9WA2

ATTRv-F33V filament from gastrocnemius muscle biopsy of an individual with a F33V mutation.

Summary for 9WA2

• Entry DOI: 10.2210/pdb9wa2/pdb
• EMDB information: 65797
• Descriptor: Transthyretin (1 entity in total)
• Functional Keywords: transthyretin amyloid filament, protein fibril
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 41187.95

Authors

Zheng, Y.,Liang, J.,Liu, Y.,Shi, Y. (deposition date: 2025-08-10, release date: 2026-07-29)

• Primary citation: Zheng, Y.,Liang, J.,Li, Z.,Liu, Y.,Chu, X.,Zhang, S.,Wang, W.,Bao, J.,Liu, B.,Ma, C.,Yin, G.,Deng, J.,Chi, W.,Meng, L.,Shi, Y.; Cryo-EM Structures of Biopsy-derived TTR Fibrils in Hereditary Transthyretin Amyloidosis; Nat Commun, 2026; DOI: 10.1038/s41467-026-75850-8

Experimental method

ELECTRON MICROSCOPY (2.4 Å)