9W7Y

Cryo-EM structure of human pyruvate kinase R (PKR) in complex with an allosteric activator BT-119106

This is a non-PDB format compatible entry.

Summary for 9W7Y

• Entry DOI: 10.2210/pdb9w7y/pdb
• EMDB information: 65437 65641 65736
• Descriptor: Pyruvate kinase PKLR, 4-[3-[1-[(2~{S})-3-oxidanyl-2-phenyl-propanoyl]azetidin-3-ylidene]azetidin-1-yl]sulfonylbenzenecarbonitrile (2 entities in total)
• Functional Keywords: pyruvate kinase pklr, glycolysis, allosteric regulation, erythroid-specific, pkd, translocase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 248463.06

Authors

Ma, H.Y.,Su, Z.M. (deposition date: 2025-08-07, release date: 2026-08-12)

• Primary citation: Ma, H.Y.,Su, Z.M.; Structural insights into allosteric activation of pyruvate kinase R by mitapivat and novel agonists; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.87 Å)