9W63

Cryo-EM structure of C20:5-CoA bound state human ABCD3 in inward-facing conformation

Summary for 9W63

• Entry DOI: 10.2210/pdb9w63/pdb
• EMDB information: 65675
• Descriptor: Isoform 1 of ATP-binding cassette sub-family D member 3,Green fluorescent protein, S-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenethioate, CHOLESTEROL (3 entities in total)
• Functional Keywords: abc transporter, transport protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 107514.89

Authors

Aiba, S.,Okamoto, H.H.,Kusakizako, T.,Nureki, O. (deposition date: 2025-08-03, release date: 2026-05-27)

• Primary citation: Aiba, S.,Okamoto, H.H.,Tomita, A.,Sano, F.,Kusakizako, T.,Nureki, O.; Structural Insights into the Broad Substrate Recognition Mechanism of Human ABCD3; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.29 Å)