9W5L

Crystal structure of KRED mutant-Y199A/N149L

Summary for 9W5L

• Entry DOI: 10.2210/pdb9w5l/pdb
• Descriptor: Short-chain dehydrogenase/reductase SDR, DIMETHYL SULFOXIDE, PHOSPHATE ION (3 entities in total)
• Functional Keywords: kred, mutants, oxidoreductase
• Biological source: Novosphingobium aromaticivorans DSM 12444
• Total number of polymer chains: 4
• Total formula weight: 107310.01

Authors

Xu, H.,Zhang, Z.,Zhang, Y.,Xu, Y.,Zhang, L. (deposition date: 2025-08-01, release date: 2026-07-08)

• Primary citation: Zhang, Z.,Zhang, Y.,Du, Z.,Zheng, X.,Xu, H.,Lin, Y.,Kong, P.,Li, H.,Cao, J.,Zhang, C.,Li, S.,Xu, Y.,Zhang, L.; Chemo-Enzymatic Synthesis of a Squalamine Intermediate by an Engineered Ketoreductase from Novosphingobium aromaticivorans; Acs Catalysis, 16:11618-11630, 2026; DOI: 10.1021/acscatal.6c03102

Experimental method

X-RAY DIFFRACTION (2.94 Å)