9W3F

Cryo-EM structure of the human beta2-adrenergic receptor in complex with a novel antagonist

Summary for 9W3F

Entry DOI	10.2210/pdb9w3f/pdb
EMDB information	65599
Descriptor	Beta-2 adrenergic receptor,Endolysin, Beta2 adrenogic receptor inactive-state stabling nanobody Nb60, BERBERINE, ... (4 entities in total)
Functional Keywords	antagonist, membrane protein, gpcr
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	72400.23
Authors	Xu, T.,Liu, X. (deposition date: 2025-07-29, release date: 2026-06-10)
Primary citation	Xu, T.,Sun, Q.,Zhang, S.,Liu, T.,Sun, X.,Wang, X.,Lin, B.,Liu, Z.,Wang, J.,He, G.,Liu, X. A negative survival pressure selection system enables GPCR antagonist screening. Cell Discov, 12:-, 2026 Cited by PubMed: 42129146 DOI: 10.1038/s41421-026-00892-7 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.04 Å)

Structure validation