9W2I

Cryo-EM structure of Peptide 336 (P336)-bound neurokinin 2 receptor (NK2R) in complex with miniGs/q70

Summary for 9W2I

• Entry DOI: 10.2210/pdb9w2i/pdb
• EMDB information: 65572
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Nanobody 35, ... (6 entities in total)
• Functional Keywords: gpcr, peptide 336 (p336), neurokinin 2 receptor (nk2r), active state, membrane protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 6
• Total formula weight: 134698.34

Authors

Ren, Y.,Pavlovskyil, A.,Liu, X.,Gerhart-Hines, Z. (deposition date: 2025-07-28, release date: 2026-06-17)

• Primary citation: Ren, Y.,Pavlovskyil, A.,Liu, X.,Gerhart-Hines, Z.; Mechanistic basis for activation and selectivity of NK2R by endogenous and synthetic peptide agonists; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.93 Å)