9VXP

Cryo-EM structure of human Pyruvate kinase R (PK-R)

Summary for 9VXP

• Entry DOI: 10.2210/pdb9vxp/pdb
• EMDB information: 65437
• Descriptor: Pyruvate kinase PKLR (1 entity in total)
• Functional Keywords: pyruvate kinase pklr, cryo-em, pklr, pkd, red cell/liver pyruvate kinase, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 218735.16

Authors

Ma, H.Y.,Su, Z.M. (deposition date: 2025-07-19, release date: 2026-07-22)

• Primary citation: Ma, H.Y.,Su, Z.M.; Structural insights into allosteric activation of pyruvate kinase R by mitapivat and novel agonists; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.48 Å)