9VVF

Crystal structure of HKU5-CoV-1 main protease(Mpro) in complex with Ensitrelvir

Summary for 9VVF

• Entry DOI: 10.2210/pdb9vvf/pdb
• Descriptor: 3C-like proteinase nsp5, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione, GLYCEROL, ... (5 entities in total)
• Functional Keywords: main protease, 3c-like protease, coronavirus, hku5-cov-1, bat coronavirus, viral protease, ensitrelvir, drug target, active site, viral protein
• Biological source: Pipistrellus bat coronavirus HKU5
• Total number of polymer chains: 1
• Total formula weight: 34131.59

Authors

Kim, H.,Lee, J.,Jung, S.,Kim, J.,Jo, I. (deposition date: 2025-07-15, release date: 2026-07-15)

• Primary citation: Kim, H.,Lee, J.,Jung, S.,Kim, J.,Jo, I.; Crystal structure of HKU5-CoV-1 main protease(Mpro) in complex with Ensitrelvir; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.55 Å)