9VUZ

an engineered light chain single-domain antibody targeting at mouse CD16

Summary for 9VUZ

• Entry DOI: 10.2210/pdb9vuz/pdb
• Descriptor: VHHL6 (1 entity in total)
• Functional Keywords: immunoglobulin, light chain, immune system
• Biological source: Homo sapiens
• Total number of polymer chains: 2
• Total formula weight: 25502.16

Authors

Wang, M.K.,Xu, Q.Y.,Yang, Z.L.,Ying, T.L.,Wu, Y.L. (deposition date: 2025-07-14, release date: 2025-11-05, Last modification date: 2025-11-26)

Primary citation

Wang, M.,Xu, Q.,Kong, Y.,Zhong, Y.,Yin, F.,Liu, L.,Yang, Z.,Ying, T.,Wu, Y.
Engineering a novel light-chain single-domain antibody to enable IgG-format bispecific antibody design.
Antib Ther, 8:301-316, 2025

PubMed Abstract: As one of the most promising classes of next-generation antibody therapeutics, bispecific antibodies (bsAbs) have gained increasing attention owing to their unique dual-targeting mechanisms. However, current bsAb formats often face challenges such as low expression levels, poor homogeneity, and unstable therapeutic efficacy due to their complex structures. Therefore, it is urgent to overcome the current technical limitations and develop novel formats of bsAbs with more stable structures and improved expression efficiency.

PubMed: 41220811
DOI: 10.1093/abt/tbaf020

Experimental method

X-RAY DIFFRACTION (3.05 Å)