9VU1

Structure of hTRPA1 complexed with LIQA

This is a non-PDB format compatible entry.

Summary for 9VU1

• Entry DOI: 10.2210/pdb9vu1/pdb
• EMDB information: 65349
• Descriptor: Transient receptor potential cation channel subfamily A member 1, Liquiritin apioside (2 entities in total)
• Functional Keywords: inhibitor, complex, ion channel, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 512844.32

Authors

Min, Y.M.,Zonglin, D.Z.,Yang, Y.Y. (deposition date: 2025-07-12, release date: 2026-07-15)

Primary citation

Yi, Y.,Duan, G.,Dai, Z.,Zhou, X.,Huang, J.,Jin, Z.,Yang, A.,Li, Y.,Huang, Z.,Ye, M.
Structural insights into TRPA1 and TRPV1 modulation by flavonoid glycosides from licorice for cough relief.
Phytomedicine, 159:158419-158419, 2026

PubMed Abstract: Transient receptor potential vanilloid 1 (TRPV1) and ankyrin 1 (TRPA1) are two nociceptive TRP channel subtypes that play central roles in cough hypersensitivity.

PubMed: 42335638
DOI: 10.1016/j.phymed.2026.158419

Experimental method

ELECTRON MICROSCOPY (2.59 Å)