9VOZ

EGFR T790M/L858R mutant in complex with covalent inhibitor TAS-121

This is a non-PDB format compatible entry.

Summary for 9VOZ

• Entry DOI: 10.2210/pdb9voz/pdb
• Descriptor: Epidermal growth factor receptor, TAS-121 (3 entities in total)
• Functional Keywords: egf receptor kinase mutant t790m, l858r, oncoprotein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 37863.85

Authors

Suzuki, T.,Uno, T. (deposition date: 2025-07-02, release date: 2026-07-15)

• Primary citation: Uno, T.,Suzuki, T.; Discovery of TAS-121 , as a Novel, Potent, Mutant Selective, Orally Available Covalent Tyrosine Kinase Inhibitor for EGFR Mutations Including T790M in Non-Small Cell Lung Cancer; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.83 Å)