9VJF

Cryo-EM structure of 5-HT1AR-Gi3 in complex with buspirone

Summary for 9VJF

• Entry DOI: 10.2210/pdb9vjf/pdb
• EMDB information: 65111
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-3, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (8 entities in total)
• Functional Keywords: signal transduction, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 177576.19

Authors

Wang, C.,Cao, C. (deposition date: 2025-06-19, release date: 2025-11-12)

• Primary citation: Wang, C.,Cao, C.; Pathway-Selective 5-HT1AR Agonist as a Rapid Antidepressant Strategy; Cell, 2025

Experimental method

ELECTRON MICROSCOPY (2.7 Å)