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9V6J

Structure-Guided Design of Picomolar-level Macrocyclic TRPC5 Channel Inhibitors with Antidepressant Activity

This is a non-PDB format compatible entry.
Summary for 9V6J
Entry DOI10.2210/pdb9v6j/pdb
EMDB information64801
DescriptorShort transient receptor potential channel 5, ZINC ION, CALCIUM ION, ... (4 entities in total)
Functional Keywordsion channel, membrane protein
Biological sourceMus musculus (house mouse)
Total number of polymer chains8
Total formula weight897916.41
Authors
Che, T.,Zhang, J.,Xiong, B.,Cheng, X.Y. (deposition date: 2025-05-27, release date: 2025-12-03)
Primary citationChe, T.,Zhang, J.,Xiong, B.,Cheng, X.Y.
Structure-Guided Design of Picomolar-level Macrocyclic TRPC5 Channel Inhibitors with Antidepressant Activity
To Be Published,
Experimental method
ELECTRON MICROSCOPY (3.23 Å)
Structure validation

245663

数据于2025-12-03公开中

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