9V31

Human claudin 18.2 (dimer form) in complex with the Fab fragment of Osemitamab (TST001)

Summary for 9V31

• Entry DOI: 10.2210/pdb9v31/pdb
• EMDB information: 64746
• Descriptor: Isoform A2 of Claudin-18, Fab of Osemitamab (TST001) - Heavy chain, Fab of Osemitamab (TST001) - Light chain (3 entities in total)
• Functional Keywords: cldn18.2, tight junction protein, therapeutic antibody, gastric cancer, membrane protein/immune system, membrane protein-immune system complex
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 146910.38

Authors

Wang, X.,Ma, H.,Fu, C.,Sun, Z.,Su, Z.,Zhou, X. (deposition date: 2025-05-21, release date: 2026-05-27)

• Primary citation: Wang, X.,Fu, C.,Ma, H.,Yang, P.,Sun, Z.,Su, Z.,Zhou, X.; Recognition of human claudin 18.2 by therapeutic antibodies; To Be Published,

Experimental method

ELECTRON MICROSCOPY (4.4 Å)