9V2U

Human claudin 18.2 in complex with the Fab fragment of Osemitamab (TST001)

Summary for 9V2U

Entry DOI	10.2210/pdb9v2u/pdb
EMDB information	64740
Descriptor	Isoform A2 of Claudin-18, Fab of Osemitamab (TST001) - Heavy chain, Fab of Osemitamab (TST001) - Light chain (3 entities in total)
Functional Keywords	cldn18.2, tight junction protein, therapeutic antibody, gastric cancer, membrane protein/immune system, membrane protein-immune system complex
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	73455.19
Authors	Wang, X.,Fu, C.,Ma, H.,Sun, Z.,Su, Z.,Zhou, X. (deposition date: 2025-05-20, release date: 2026-05-27)
Primary citation	Wang, X.,Fu, C.,Ma, H.,Yang, P.,Sun, Z.,Su, Z.,Zhou, X. Recognition of human claudin 18.2 by therapeutic antibodies To Be Published,
Experimental method	ELECTRON MICROSCOPY (3.8 Å)

Structure validation