9V0C

Cryo-EM structure of iberdomide-organized CRL4-DDB1-CRBN-IKZF3(ZF2-ZF3)-UbcH5a-Ub ubiquitylation assembly

Summary for 9V0C

Entry DOI	10.2210/pdb9v0c/pdb
EMDB information	64661
Descriptor	Protein cereblon, (3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, Cullin-4A, ... (10 entities in total)
Functional Keywords	molecular glue degrader, iberdomide, crl4 ubiquitin ligase, ddb1, crbn, complex, ligase
Biological source	Homo sapiens (human) More
Total number of polymer chains	8
Total formula weight	318831.40
Authors	Deng, Z.H.,Ai, H.S.,Liu, L. (deposition date: 2025-05-17, release date: 2026-08-19)
Primary citation	Deng, Z.H.,Ai, H.S.,Liu, L. Cryo-EM structure of iberdomide-organized CRL4-DDB1-CRBN-IKZF3(ZF2-ZF3)-UbcH5a-Ub ubiquitylation assembly To Be Published,
Experimental method	ELECTRON MICROSCOPY (3.27 Å)

Structure validation