9V0B

Cryo-EM structure of avadomide-organized CRL4-DDB1-CRBN-IKZF3(ZF2-ZF3)-UbcH5a-Ub ubiquitylation assembly

Summary for 9V0B

Entry DOI	10.2210/pdb9v0b/pdb
EMDB information	64660
Descriptor	Cullin-4A, (3S)-3-(5-azanyl-2-methyl-4-oxidanylidene-quinazolin-3-yl)piperidine-2,6-dione, DNA damage-binding protein 1, ... (10 entities in total)
Functional Keywords	molecular glue degrader, avadomide, crl4 ubiquitin ligase, ddb1, crbn, complex, ligase
Biological source	Homo sapiens (human) More
Total number of polymer chains	8
Total formula weight	318668.19
Authors	Deng, Z.H.,Ai, H.S.,Liu, L. (deposition date: 2025-05-17, release date: 2026-06-10)
Primary citation	Deng, Z.H.,Ai, H.S.,Liu, L. Cryo-EM structure of avadomide-organized CRL4-DDB1-CRBN-IKZF3(ZF2-ZF3)-UbcH5a-Ub ubiquitylation assembly To Be Published,
Experimental method	ELECTRON MICROSCOPY (3.54 Å)

Structure validation