9UUQ

Cryo-EM structure of thalidomide-organized CRL4-DDB1-CRBN-IKZF3(ZF2-ZF3)-UbcH5a-Ub ubiquitylation assembly

Summary for 9UUQ

• Entry DOI: 10.2210/pdb9uuq/pdb
• EMDB information: 64515
• Descriptor: Cullin-4A, ZINC ION, DNA damage-binding protein 1, ... (10 entities in total)
• Functional Keywords: molecular glue degrader, thalidomide, crl4 ubiquitin ligase, ddb1, crbn, complex, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 318640.13

Authors

Deng, Z.H.,Ai, H.S.,Liu, L. (deposition date: 2025-05-07, release date: 2026-08-19)

• Primary citation: Deng, Z.H.,Ai, H.S.,Liu, L.; Cryo-EM structure of mezigdomide-organized CRL4-DDB1-CRBN-IKZF3(ZF2-ZF3)-UbcH5a-Ub ubiquitylation assembly; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.41 Å)