9UIP

Cryo-EM structure of the human NK1 tachykinin receptor bound to the antagonist aprepitant resolved via the fusion/crosslinking strategy

Summary for 9UIP

• Entry DOI: 10.2210/pdb9uip/pdb
• EMDB information: 64200
• Descriptor: Substance-P receptor, Green fluorescent protein, GFP-clamp E186C, ... (4 entities in total)
• Functional Keywords: human nk1 tachykinin receptor; fusion/crosslinking strategy; aprepitant., membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 94751.40

Authors

Han, S.C.,Li, M.H. (deposition date: 2025-04-16, release date: 2026-10-28)

• Primary citation: Han, S.C.,Li, M.H.; Cryo-EM structure determination of GPCRs with disulfide-crosslinked fusion protein; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.85 Å)