9UGO

Cryo-EM structure of the HBsAg dimer and Complex with Fab

Summary for 9UGO

• Entry DOI: 10.2210/pdb9ugo/pdb
• EMDB information: 64142
• Descriptor: Fab light chain, Fab heavy chain, Middle S protein (3 entities in total)
• Functional Keywords: hbv antigen, dimer, fab, complex, viral protein/immune system, viral protein-immune system complex
• Biological source: Homo sapiens; More
• Total number of polymer chains: 6
• Total formula weight: 117110.68

Authors

Liu, Y.,Liao, M.,Liu, Z.,Ju, B.,Zhang, Z. (deposition date: 2025-04-13, release date: 2026-02-18)

Primary citation

Ju, B.,Liu, Z.,Yan, H.,Liu, Y.,Zhang, L.,Ge, X.,Wang, X.,Si, Z.,Zhou, B.,Fan, Q.,Wang, M.,Li, Y.,Lai, W.,Gan, J.,Wang, H.,Zhao, J.,Xia, Y.,Liao, M.,Zhang, Z.
Characterisation of plasmablast-derived HBsAg-specific antibody and its structural basis for binding to native HBsAg dimer.
Gut, 2026

PubMed Abstract: Plasmablast-derived HBV surface antigen (HBsAg)-specific monoclonal antibody (mAb) and structural basis for binding to native HBsAg are poorly known.

PubMed: 41663152
DOI: 10.1136/gutjnl-2025-336641

Experimental method

ELECTRON MICROSCOPY (4 Å)