9UGJ

Structure of SARM1 bound to SIR3-ADPR

This is a non-PDB format compatible entry.

Summary for 9UGJ

• Entry DOI: 10.2210/pdb9ugj/pdb
• EMDB information: 64139
• Descriptor: NAD(+) hydrolase SARM1, [[(2~{S},3~{R},4~{S},5~{S})-5-(4-azanylimidazo[4,5-d]pyridazin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-[4-methyl-3-(2-oxidanylidene-3~{H}-1,3-benzoxazol-6-yl)pyridin-1-ium-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate (2 entities in total)
• Functional Keywords: nad(+) hydrolase, cell death, apoptosis, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 8
• Total formula weight: 677674.69

Authors

Zhang, J.,Zheng, S.,Wang, X. (deposition date: 2025-04-12, release date: 2026-02-18)

• Primary citation: Zhang, W.,Zhou, Q.,Zhang, J.,Zheng, S.,Wang, X.; SARM1 Activation Promotes Axonal Degeneration Via a Two-Step Liquid-to-Solid Phase Transition; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.85 Å)