9U99

Crystal structure of KRAS-G12D/E62K mutant in complex with MRTX-1133

Summary for 9U99

• Entry DOI: 10.2210/pdb9u99/pdb
• Descriptor: Isoform 2B of GTPase KRas, 4-(4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2R,4R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
• Functional Keywords: complex structure, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 90689.60

Authors

Zhang, X.L.,Zhang, X.Y.,Zhang, Y.Z.,Xu, C.,Liu, L.,Bai, F. (deposition date: 2025-03-27, release date: 2026-03-25)

• Primary citation: Zhang, X.L.,Zhang, X.Y.,Zhang, Y.Z.,Bai, F.; Molecule Mechanisms of KRAS Secondery Mutation Conferred Resistance of MRTX1133; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.5 Å)