9U8L

Crystal structure of KRAS-G12D/Y96S mutant in complex with MRTX-1133

Summary for 9U8L

• Entry DOI: 10.2210/pdb9u8l/pdb
• Descriptor: Isoform 2B of GTPase KRas, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
• Functional Keywords: complex structure, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 22596.24

Authors

Zhang, X.L.,Zhang, X.Y.,Zhang, Y.Z.,Xu, C.,Liu, L.,Bai, F. (deposition date: 2025-03-26, release date: 2026-04-01)

• Primary citation: Zhang, X.L.,Zhang, X.Y.,Zhang, Y.Z.,Bai, F.; Molecule Mechanisms of KRAS Secondery Mutation Conferred Resistance of MRTX1133; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.23 Å)