9U5Y

Crystal structure of cytochrome P450 mutant-T288G S289Q G290E T291I of CYP161H12 from Amycolatopsis pretoriensis

Summary for 9U5Y

Entry DOI	10.2210/pdb9u5y/pdb
Related	8W7G
Descriptor	Pentalenolactone synthase, PROTOPORPHYRIN IX CONTAINING FE (3 entities in total)
Functional Keywords	cyp, p450, pentaclyclic triterpenoids, oxidation, cytochrome, amycolatopsis, pretoriensis, oxidoreductase, biosynthetic protein
Biological source	Amycolatopsis pretoriensis
Total number of polymer chains	1
Total formula weight	44195.52
Authors	Dong, L.B.,Zhang, X.W.,Wang, Y.X.,Pan, X.M.,Liu, C.H. (deposition date: 2025-03-22, release date: 2026-03-25)
Primary citation	Zhang, X.W.,Wang, Y.X.,Dong, L.B. Reshape the Active Pocket of ApPT for Divergent Synthesis of Pentacyclic Triterpenoids with Expanded Chemical Space in B-Ring. To Be Published,
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation