9TPW

cryo-ET structure of mTOR complex 2 on a PIP2-containing membrane

Summary for 9TPW

• Entry DOI: 10.2210/pdb9tpw/pdb
• EMDB information: 56117
• Descriptor: Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, Rapamycin-insensitive companion of mTOR, ... (5 entities in total)
• Functional Keywords: kinase, complex, signaling protein, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 1168373.54

Authors

Hay, I.M.,Ahsan, B.,Williams, R.L. (deposition date: 2025-12-18, release date: 2026-04-22)

• Primary citation: Hay, I.M.,Bourguet, M.,Ahsan, B.,Perisic, O.,Anandapadamanaban, M.,Williams, R.L.; Structural basis for a phosphoinositide-driven mTORC2-AKT positive feedback loop; Biorxiv, 2026; DOI: 10.64898/2026.01.08.698367

Experimental method

ELECTRON MICROSCOPY (6.4 Å)