9TLP

De novo designed single-chain antiparallel coiled-coil hairpin with binding site for BCL-xL, Sc-apCC-2-BCL-xL-6

Summary for 9TLP

Entry DOI	10.2210/pdb9tlp/pdb
Descriptor	Sc-apCC-2-BCL-xL-6 (2 entities in total)
Functional Keywords	protein binder, computational design, coiled-coil, de novo protein
Biological source	synthetic construct
Total number of polymer chains	4
Total formula weight	34383.64
Authors	Mylemans, B.,Woolfson, D.N. (deposition date: 2025-12-11, release date: 2026-08-19)
Primary citation	Mylemans, B.,Korona, B.,Acevedo-Jake, A.M.,MacRae, A.,Edwards, T.A.,Huang, D.T.,Wilson, A.J.,Itzhaki, L.S.,Woolfson, D.N. De Novo-Designed Bifunctional J.Am.Chem.Soc., 2026 Cited by DOI: 10.1021/jacs.6c07593 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation