9TKA

Structure of human CLN8 in the presence of oleate

Summary for 9TKA

• Entry DOI: 10.2210/pdb9tka/pdb
• EMDB information: 56022
• Descriptor: Protein CLN8, COENZYME A, OLEIC ACID, ... (4 entities in total)
• Functional Keywords: bis(monoacylglycero)phosphate, batten disease, glycerophosphoglycerol, lysophosphatidylglycerol, acyltransferase, neurodegeneration, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 34582.99

Authors

Lacabanne, D.,Sheokand, P.K.,Ruprecht, J.J.,Petkevicius, K. (deposition date: 2025-12-09, release date: 2026-07-29)

• Primary citation: Sheokand, P.K.,Lacabanne, D.,James, A.M.,Ruprecht, J.J.,van der Kleij, J.,Muller-Niva, J.,Salo, M.H.,Juneja, N.,Jenkins, J.,Shun Yu, C.,Pratt, M.A.,King, M.S.,Weimer, J.M.,Koulman, A.,Hinttala, R.,Santorelli, F.M.,Murphy, M.P.,Kunji, E.R.S.,Petkevicus, K.; Stereospecific GPG acylation by CLN8 drives BMP biosynthesis and underpins Batten disease; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.7 Å)