9TFL

KIT kinase domain in complex with a methyl quinazoline-7-carboxylate-based compound (41)

Summary for 9TFL

Entry DOI	10.2210/pdb9tfl/pdb
Descriptor	Mast/stem cell growth factor receptor Kit, methyl 4-[4-[5-[(1~{S})-1-azanyl-1-(4-fluorophenyl)ethyl]pyrimidin-2-yl]piperazin-1-yl]quinazoline-7-carboxylate (3 entities in total)
Functional Keywords	kit protein kinase, inhibitor, tyrosine kinase, transmembrane receptor, stem cell factor, scf, stem cell factor receptor, gist, gastrointestinal stromal tumors, p10721, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	75363.92
Authors	Scrima, A.,Mueller, M.P.,Rauh, D. (deposition date: 2025-11-27, release date: 2026-07-15)
Primary citation	Schulz, T.,Beerbaum, M.,Scrima, A.,Jantzen, H.,Teuber, A.,Muehlenberg, T.,Garcia-Fossa, F.,Weisner, J.,Mueller, M.P.,Sievers, S.,Bauer, S.,Rauh, D. Structure-based Scaffold Hopping Reveals Strategies to Overcome Oncogenic KIT and PDGFRA Mutation-Driven Drug-Resistance in GIST To Be Published,
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation