9TFD
KIT kinase domain in complex with a pyrrolotriazine-based compound (11)
This is a non-PDB format compatible entry.
Summary for 9TFD
| Entry DOI | 10.2210/pdb9tfd/pdb |
| Descriptor | Mast/stem cell growth factor receptor Kit, 6-(1-methylpyrazol-4-yl)-4-[4-[5-(phenylmethyl)pyrimidin-2-yl]piperazin-1-yl]pyrrolo[2,1-f][1,2,4]triazine (3 entities in total) |
| Functional Keywords | kit protein kinase, inhibitor, tyrosine kinase, transmembrane receptor, stem cell factor, scf, stem cell factor receptor, gist, gastrointestinal stromal tumors, p10721, transferase |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 75291.91 |
| Authors | |
| Primary citation | Schulz, T.,Beerbaum, M.,Scrima, A.,Jantzen, H.,Teuber, A.,Muehlenberg, T.,Garcia-Fossa, F.,Weisner, J.,Mueller, M.P.,Sievers, S.,Bauer, S.,Rauh, D. Structure-based Scaffold Hopping Reveals Strategies to Overcome Oncogenic KIT and PDGFRA Mutation-Driven Drug-Resistance in GIST To Be Published, |
| Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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