9T95

Crystal structure of beta-TrCP bound by diphosphorylated NRF2 degron peptide.

Summary for 9T95

Entry DOI	10.2210/pdb9t95/pdb
Descriptor	F-box/WD repeat-containing protein 1A, Nuclear factor erythroid 2-related factor 2 (3 entities in total)
Functional Keywords	beta-trcp, e3 ligase, phosphodegron, nrf2, ligase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	43198.86
Authors	Collie, G.W. (deposition date: 2025-11-13, release date: 2026-04-08)
Primary citation	O Donovan, D.H.,Winter-Holt, J.,Collie, G.W.,Cuomo, M.E.,McGarry, D.J.,Fox, M.,Alex Seong, B.K.,Grazini, U.,Barton, P.,Longmire, D.,Lister, A.,Xu, Y.,Mak, H.,Barrey, E.J.,Acebron-Garcia-de-Eulate, M.,Richter, M.,Peter, N.,Couturier, M.,Gutierrez, G.J.,Guilbert, R.,Lee, W.,Lochhead, P.A.,Argyrou, A. Targeting the Interaction of NRF2 and beta-TrCP with Molecular Glues Acs Chem.Biol., 2026 Cited by DOI: 10.1021/acschembio.5c01006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.145 Å)

Structure validation