9T7J

cryo-EM structure of AKT phosphorylated mTOR complex 2, overall refinement

Summary for 9T7J

• Entry DOI: 10.2210/pdb9t7j/pdb
• EMDB information: 55637
• Descriptor: Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, Rapamycin-insensitive companion of mTOR, ... (8 entities in total)
• Functional Keywords: kinase, complex, signaling protein, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 1171722.32

Authors

Hay, I.M.,Anandapadamanaban, M.,Williams, R.L. (deposition date: 2025-11-10, release date: 2026-04-22)

• Primary citation: Hay, I.M.,Bourguet, M.,Ahsan, B.,Perisic, O.,Anandapadamanaban, M.,Williams, R.L.; Structural basis for a phosphoinositide-driven mTORC2-AKT positive feedback loop; Biorxiv, 2026; DOI: 10.64898/2026.01.08.698367

Experimental method

ELECTRON MICROSCOPY (3 Å)