9T73

Tetrapodal ancestor of L-amino acid oxidase: I224A-Q225H-P361-PREGA-L367 mutant bound to phenylalanine

Summary for 9T73

• Entry DOI: 10.2210/pdb9t73/pdb
• Descriptor: Tetrapodal ancestor of L-amino acid oxidases: I224A-Q225H-P361-PREGA-L367 bound to phenylalanine, FLAVIN-ADENINE DINUCLEOTIDE, PHENYLALANINE (3 entities in total)
• Functional Keywords: tryptophan, metabolic signaling, oxidation, fad, snake venom, immunometabolism, oxidoreductase
• Biological source: Tetrapoda
• Total number of polymer chains: 4
• Total formula weight: 224548.66

Authors

Massari, M.,Mattevi, A.,Caroli, J. (deposition date: 2025-11-10, release date: 2026-08-05)

• Primary citation: Massari, M.,Caroli, J.,Malatesta, M.,Marchese, S.,Sente, F.,Pizzorni, L.,Mattevi, A.; Evolution of Human IL4i1 Preference for Aromatic Amino Acids from a Broad-Specificity L-Amino Acid Oxidase Ancestor; PNAS, 2026

Experimental method

X-RAY DIFFRACTION (2.82 Å)