9T5O

Structure of heteromeric mouse LRRC8A/D Volume-Regulated Anion Channel in complex with synthetic nanobody Sb1, Conformation 2

Summary for 9T5O

• Entry DOI: 10.2210/pdb9t5o/pdb
• EMDB information: 55591
• Descriptor: Volume-regulated anion channel subunit LRRC8A, Synthetic Nanobody Sb1, Volume-regulated anion channel subunit LRRC8D (3 entities in total)
• Functional Keywords: heteromeric lrrc8 protein, cell swelling, membrane protein
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 10
• Total formula weight: 643831.26

Authors

Lehmann, E.F.,Deneka, D.,Stierli, F.,Rutz, S.,Dutzler, R. (deposition date: 2025-11-05, release date: 2026-09-02)

• Primary citation: Lehmann, E.F.,Deneka, D.,Stierli, F.,Rutz, S.,Dutzler, R.; Structures of the volume-regulated anion channel LRRC8A/D in activating and inhibiting conditions; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.16 Å)