9T1P

Human PI3Kdelta in complex with IOA-288

This is a non-PDB format compatible entry.

Summary for 9T1P

• Entry DOI: 10.2210/pdb9t1p/pdb
• Related: 9T07
• Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, [7-fluoranyl-1-[(3~{R})-1-(2-morpholin-4-ylethyl)piperidin-3-yl]-5,5-bis(oxidanylidene)-4~{H}-thiochromeno[4,3-c]pyrazol-3-yl]-morpholin-4-yl-methanone, ... (4 entities in total)
• Functional Keywords: pi3kdelta kinase, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 141060.22

Authors

Graedler, U.,Augustin, M.,Goesser, C.,Kiefersauer, R. (deposition date: 2025-10-21, release date: 2026-07-08)

• Primary citation: Graedler, U.,Augustin, M.; Roginolisib selectively inhibits PI3Kdelta by stabilizing the C-terminal helix kalpha12; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.97 Å)