9T1L

Tetrapodal ancestor of L-amino acid oxidases: W377I mutant bound to phenylalanine

Summary for 9T1L

• Entry DOI: 10.2210/pdb9t1l/pdb
• Descriptor: Tetrapodal ancestor of L-amino acid oxidases: W377I mutant, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... (6 entities in total)
• Functional Keywords: tryptophan, metabolic signaling, oxidation, fad, snake venom, immunometabolism, oxidoreductase
• Biological source: Tetrapoda
• Total number of polymer chains: 2
• Total formula weight: 113401.45

Authors

Caroli, J.,Mattevi, A. (deposition date: 2025-10-21, release date: 2026-08-05)

• Primary citation: Massari, M.,Caroli, J.,Malatesta, M.,Marchese, S.,Sente, F.,Pizzorni, L.,Mattevi, A.; Evolution of Human IL4i1 Preference for Aromatic Amino Acids from a Broad-Specificity L-Amino Acid Oxidase Ancestor; PNAS, 2026

Experimental method

X-RAY DIFFRACTION (1.84 Å)