9T15

Crystal structure of human BRD4-BD1 bromodomain in complex with compound 662

This is a non-PDB format compatible entry.

Summary for 9T15

• Entry DOI: 10.2210/pdb9t15/pdb
• Descriptor: Bromodomain-containing protein 4, ~{N}-[2,4-bis(oxidanyl)phenyl]-2-[(2~{R})-5-oxidanylidenepyrrolidin-2-yl]ethanamide, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: inhibitor, bromodomain fold, acetyl-lysine binding pocket, complex, cell cycle
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 18067.47

Authors

Morozova, I.,Elizarova, E.,Lau, K.,Pojer, F.,Schneuing, A.,Gampp, O.,Igashov, I.,Correia, B. (deposition date: 2025-10-21, release date: 2026-11-04)

• Primary citation: Elizarova, E.,Morozova, I.,Igashov, I.,Iosub, D.,Schneuing, A.,Lau, K.,Ferraris, D.,Pojer, F.,Riek, R.,Bronstein, M.,Correia, B.; FragmentScope - exploring the fragment space with learned surface representations; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.214 Å)