9T0O
Solution structure of Nanofitin C10 in complex with a 12unit aromatic oligoamide foldamer
This is a non-PDB format compatible entry.
Summary for 9T0O
| Entry DOI | 10.2210/pdb9t0o/pdb |
| NMR Information | BMRB: 53317 |
| Descriptor | Foldamer-binding Nanofitin C10, Aromatic oligoamide foldamer (2 entities in total) |
| Functional Keywords | protein-foldamer complex, de novo protein |
| Biological source | Sulfolobus acidocaldarius More |
| Total number of polymer chains | 2 |
| Total formula weight | 10688.83 |
| Authors | Largy, E.,Morozov, V.,Huc, I.,Mackereth, C.D. (deposition date: 2025-10-17, release date: 2026-10-07) |
| Primary citation | Sigl, J.,Morozov, V.,Wang, L.,Sachs, J.,Merlet, E.,Largy, E.,Geue, N.,Osterlund, N.,Kwon, S.,Sanchez, F.,Candela, L.,Huet, S.,Pagel, K.,Ferrand, Y.,Douat, C.,Mackereth, C.D.,Huc, I. A protein-foldamer supramolecular synthon for self-assembled hybrid architectures. Nat.Chem., 2026 Cited by PubMed Abstract: Constructing artificial assemblies that combine proteins and synthetic ligands has been hampered by the lack of protein-ligand interfaces that are sufficiently large and organized to enable precise structural control. Here ribosome display selection is used to identify a protein that binds a helical aromatic foldamer both tightly and selectively through a sizeable surface area. We used this complex as a supramolecular synthon to create well-defined hybrid foldamer-protein architectures. Examples include foldamers that bind two proteins and hold them at a precise distance, proteins that bind two foldamers and crystals in which proteins and foldamers are connected in cyclic or infinite arrays. The modularity of aromatic foldamers brings a further dimension to protein-based assemblies. PubMed: 42608459DOI: 10.1038/s41557-026-02222-6 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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