9SZH

Crystal structure of the human METTL3-METTL14 in complex with PIPC4

This is a non-PDB format compatible entry.

Summary for 9SZH

• Entry DOI: 10.2210/pdb9szh/pdb
• Descriptor: N6-adenosine-methyltransferase catalytic subunit, N(6)-adenosine-methyltransferase non-catalytic subunit METTL14, 2-[(3~{R})-2,6-bis(oxidanylidene)piperidin-3-yl]-4-[[4-[4-[2-[[6-[4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]-2,5-bis(fluoranyl)phenyl]-2-oxidanylidene-1,4,9-triazaspiro[5.5]undecan-9-yl]pyrimidin-4-yl]amino]ethyl]piperazin-1-yl]-4-oxidanylidene-butyl]amino]isoindole-1,3-dione, ... (5 entities in total)
• Functional Keywords: mettl3, inhibitor, complex, m6a, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 62720.40

Authors

Bedi, R.K.,Caflisch, A. (deposition date: 2025-10-14, release date: 2026-10-28)

• Primary citation: Bedi, R.K.,Caflisch, A.; Crystal structure of the human METTL3-METTL14 in complex with PIPC4; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.54 Å)