9SZF

Crystal structure of the human METTL3-METTL14 in complex with COD_ME_27

This is a non-PDB format compatible entry.

Summary for 9SZF

• Entry DOI: 10.2210/pdb9szf/pdb
• Descriptor: N6-adenosine-methyltransferase catalytic subunit, N(6)-adenosine-methyltransferase non-catalytic subunit METTL14, ~{N}-(2-methylpropyl)-2-[4-[[5-(7-oxa-2-azaspiro[3.5]nonan-2-yl)-1-oxidanylidene-2,7-naphthyridin-2-yl]methyl]phenyl]-~{N}-[[(2~{S})-piperidin-2-yl]methyl]ethanamide, ... (5 entities in total)
• Functional Keywords: mettl3, inhibitor, complex, m6a, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 62339.07

Authors

Bedi, R.K.,Caflisch, A. (deposition date: 2025-10-14, release date: 2026-10-28)

• Primary citation: Bedi, R.K.,Caflisch, A.; Crystal structure of the human METTL3-METTL14 in complex with COD_ME_27; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.82 Å)