9SZ8

Crystal structure of the human METTL3-METTL14 in complex with COD_ME_26

This is a non-PDB format compatible entry.

Summary for 9SZ8

• Entry DOI: 10.2210/pdb9sz8/pdb
• Descriptor: N6-adenosine-methyltransferase catalytic subunit, N(6)-adenosine-methyltransferase non-catalytic subunit METTL14, ~{N}-[[4-[2-[2-methylpropyl-[[(2~{R})-piperidin-2-yl]methyl]amino]-2-oxidanylidene-ethyl]phenyl]methyl]-4-oxidanylidene-pyrido[1,2-a]pyrimidine-2-carboxamide, ... (5 entities in total)
• Functional Keywords: mettl3, inhibitor, complex, m6a, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 62256.92

Authors

Bedi, R.K.,Caflisch, A. (deposition date: 2025-10-14, release date: 2026-11-04)

• Primary citation: Bedi, R.K.,Caflisch, A.; Crystal structure of the human METTL3-METTL14 in complex with COD_ME_26; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.65 Å)