9SZ6

Crystal structure of the human METTL3-METTL14 in complex with COD_ME_05

This is a non-PDB format compatible entry.

Summary for 9SZ6

• Entry DOI: 10.2210/pdb9sz6/pdb
• Descriptor: N6-adenosine-methyltransferase catalytic subunit, N(6)-adenosine-methyltransferase non-catalytic subunit METTL14, 2-[[6-[[(3-fluoranyl-1-bicyclo[1.1.1]pentanyl)methylamino]methyl]imidazo[1,2-a]pyridin-2-yl]methyl]-5-(7-oxa-2-azaspiro[3.5]nonan-2-yl)-2,7-naphthyridin-1-one, ... (5 entities in total)
• Functional Keywords: mettl3, inhibitor, complex, m6a, rna binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 62295.93

Authors

Bedi, R.K.,Caflisch, A. (deposition date: 2025-10-14, release date: 2026-11-04)

• Primary citation: Bedi, R.K.,Caflisch, A.; Crystal structure of the human METTL3-METTL14 in complex with COD_ME_05; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.57 Å)