9SZ4

Crystal structure of the human METTL3-METTL14 in complex with COD_ME_04

This is a non-PDB format compatible entry.

Summary for 9SZ4

• Entry DOI: 10.2210/pdb9sz4/pdb
• Descriptor: N6-adenosine-methyltransferase catalytic subunit, N(6)-adenosine-methyltransferase non-catalytic subunit METTL14, 1-[2-[[4-[5-[3,3-bis(fluoranyl)pyrrolidin-1-yl]pyridin-3-yl]-1,2,3-triazol-1-yl]methyl]imidazo[1,2-a]pyridin-6-yl]-~{N}-(cyclobutylmethyl)methanamine, ... (5 entities in total)
• Functional Keywords: mettl3, inhibitor, complex, m6a, rna binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 62245.85

Authors

Bedi, R.K.,Caflisch, A. (deposition date: 2025-10-14, release date: 2026-11-04)

• Primary citation: Bedi, R.K.,Caflisch, A.; Crystal structure of the human METTL3-METTL14 in complex with COD_ME_04; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.59 Å)