9SZ1

Crystal structure of the human METTL3-METTL14 in complex with COD_122

This is a non-PDB format compatible entry.

Summary for 9SZ1

• Entry DOI: 10.2210/pdb9sz1/pdb
• Descriptor: N6-adenosine-methyltransferase catalytic subunit, N(6)-adenosine-methyltransferase non-catalytic subunit METTL14, 4-[4-[[(4~{a}~{S},7~{a}~{R})-1-methyl-3,4~{a},5,6,7,7~{a}-hexahydro-2~{H}-cyclopenta[b]pyrazin-4-yl]methyl]-2,5-bis(fluoranyl)phenyl]-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one, ... (5 entities in total)
• Functional Keywords: mettl3, inhibitor, complex, m6a, rna binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 62307.97

Authors

Bedi, R.K.,Caflisch, A. (deposition date: 2025-10-14, release date: 2026-11-04)

• Primary citation: Bedi, R.K.,Caflisch, A.; Crystal structure of the human METTL3-METTL14 in complex with COD_122; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.65 Å)